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The 2.4 mg pen is the standard maintenance dose, studied in STEP-1 with mean 15% body weight loss over 68 weeks (intent-to-treat)

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Future investigations should incorporate high-resolution joint-tissue single-cell transcriptomics, long-term OA models, and clinically stratified cohorts to further elucidate the diagnostic utility and mechanistic function of LPCAT3 in OA pathogenesis